The hbhA Gene of Mycobacterium tuberculosis Is Specifically Upregulated in the Lungs but Not in the Spleens of Aerogenically Infected Mice
Open Access
- 1 May 2006
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (5) , 3006-11
Abstract
We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.Keywords
This publication has 31 references indexed in Scilit:
- Mycobacterium tuberculosis heparin-binding haemagglutinin adhesin (HBHA) triggers receptor-mediated transcytosis without altering the integrity of tight junctionsMicrobes and Infection, 2006
- Mechanisms of Azole Resistance in Clinical Isolates of Candida glabrata Collected during a Hospital Survey of Antifungal ResistanceAntimicrobial Agents and Chemotherapy, 2005
- Magnetic Resonance Imaging of Pulmonary Lesions in Guinea Pigs Infected withMycobacterium tuberculosisInfection and Immunity, 2004
- Effect of Growth State on Transcription Levels of Genes Encoding Major Secreted Antigens of Mycobacterium tuberculosis in the Mouse LungInfection and Immunity, 2004
- Concentration and Assembly of the Division Ring Proteins FtsZ, FtsA, and ZipA during theEscherichia coliCell CycleJournal of Bacteriology, 2003
- DNA Vaccine Combinations Expressing Either Tissue Plasminogen Activator Signal Sequence Fusion Proteins or Ubiquitin-Conjugated Antigens Induce Sustained Protective Immunity in a Mouse Model of Pulmonary TuberculosisInfection and Immunity, 2002
- The Mycobacterium tuberculosis ECF sigma factor σE: role in global gene expression and survival in macrophages†Molecular Microbiology, 2001
- A Novel Method to Compensate for Different Amplification Efficiencies between Patient DNA Samples in Quantitative Real-Time PCRThe Journal of Molecular Diagnostics, 2001
- Identification of a heparin-binding hemagglutinin present in mycobacteria.Journal of Experimental Medicine, 1996
- Protection to mice afforded by bcg vaccines against an aerogenic challenge by three mycobacteria of decreasing virulenceTubercle, 1985