MiRNAs and Cancer: Key Link in Diagnosis and Therapy

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Abstract
Since the discovery of the first microRNA (miRNA), the exploration of miRNA biology has come to a new era in recent decades. Monumental studies have proven that miRNAs can be dysregulated in different types of cancers and the roles of miRNAs turn out to function to either tumor promoters or tumor suppressors. The interplay between miRNAs and the development of cancers has grabbed attention of miRNAs as novel tools and targets for therapeutic attempts. Moreover, the development of miRNA delivery system accelerates miRNA preclinical implications. In this review, we depict recent advances of miRNAs in cancer and discuss the potential diagnostic or therapeutic approaches of miRNAs.
Funding Information
  • National Natural Science Foundation of China (81672594, 81872139, 82072907)
  • Guangzhou Regenerative Medicine and Health Guangdong Laboratory (2018GZR0201004)
  • Sun Yat-sen memorial hospital cultivation project for clinical research (SYS-C-201805)
  • Key Projects of The National Natural Science Foundation of China (51861125203)
  • Project of The Beijing Xisike Clinical Oncology Research Foundation (Y-Roche2019/2-0078)
  • Technology Development Programof Guangdong province (2021A0505030082)
  • Project of The Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation (2020B1212060018OF007)

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