Long-Range DNA Charge Transport
Authors:
- 1 August 2003
- journal article
- review article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (17) , 6475-6483
Abstract
The stack of base pairs within double helical DNA has been shown to mediate charge transport reactions. Charge transport through DNA can result in chemistry at a distance, yielding oxidative DNA damage at a site remote from the bound oxidant. Since DNA charge transport chemistry depends on coupling within the stacked base pair array, this chemistry is remarkably sensitive to sequence-dependent DNA structure and dynamics. Here, we discuss different features of DNA charge transport chemistry, including applications as well as possible biological consequences and opportunities.Keywords
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