Tularemia Vaccines: Recent Developments and Remaining Hurdles
- 28 April 2011
- journal article
- review article
- Published by Taylor & Francis in Future Microbiology
- Vol. 6 (4) , 391-405
Abstract
Francisella tularensis subsp. tularensis is a facultative intracellular bacterial pathogen of humans and other mammals. Its inhaled infectious dose is very low and can result in very high mortality. Historically, subsp. tularensis was developed as a biological weapon and there are now concerns about its abuse as such by terrorists. A live attenuated vaccine developed pragmatically more than half a century ago from the less virulent holarctica subsp. is the sole prophylactic available, but it remains unlicensed. In recent years several other potential live, killed and subunit vaccine candidates have been developed and tested in mice for their efficacy against respiratory challenge with subsp. tularensis. This article will review these vaccine candidates and the development hurdles they face.Keywords
Funding Information
- National Research Council
This publication has 94 references indexed in Scilit:
- Long lived protection against pneumonic tularemia is correlated with cellular immunity in peripheral, not pulmonary, organsVaccine, 2010
- Detoxified Endotoxin Vaccine (J5dLPS/OMP) Protects Mice Against Lethal Respiratory Challenge with Francisella tularensis SchuS4Vaccine, 2010
- Vaccination of Fischer 344 rats against pulmonary infections by Francisella tularensis type A strainsVaccine, 2009
- Recombinant attenuated Listeria monocytogenes vaccine expressing Francisella tularensis IglC induces protection in mice against aerosolized Type A F. tularensisVaccine, 2009
- Cellular and humoral immunity are synergistic in protection against types A and B Francisella tularensisVaccine, 2008
- An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strainVaccine, 2008
- Molecular immunology of experimental primary tularemia in mice infected by respiratory or intradermal routes with type A Francisella tularensisMolecular Immunology, 2008
- An improved Francisella tularensis live vaccine strain (LVS) is well tolerated and highly immunogenic when administered to rabbits in escalating doses using various immunization routesVaccine, 2008
- Oral immunization of mice with the live vaccine strain (LVS) of Francisella tularensis protects mice against respiratory challenge with virulent type A F. tularensisVaccine, 2007
- Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccinationMolecular Immunology, 2007