Association of QTc Formula With the Clinical Management of Patients With Cancer

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Abstract
Prolongation of the QT interval is a common adverse event associated with many chemotherapeutic agents and can lead to life-threatening arrhythmias such as torsades de pointes (TdP). Thus, monitoring of the QT interval is critical to mitigate the risk of cardiac complications of cancer treatment. Duration of the QT interval naturally varies inversely with heart rate; hence, a corrected QT (QTc) that is adjusted for heart rate is most predictive of proarrhythmic potential.1-3 The QTc is widely used in clinical practice. However, key aspects of QTc monitoring lack standardization in oncology, leading to variation in practice patterns that may ultimately compromise care.

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