Inhibition of Ras–effector interactions by cyclic peptides
- 27 November 2012
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in MedChemComm
- Vol. 4 (2) , 378-382
Abstract
A combinatorial library of 6 × 106 cyclic peptides was synthesized in the one bead-two compound format, with each bead displaying a unique cyclic peptide on its surface and a linear peptide encoding tag in its interior. Screening of the library against K-Ras identified compounds that bound K-Ras with submicromolar affinity and disrupted its interaction with effector proteins.Keywords
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