PHARMACOKINETICS AND BIOAVAILABILITY OF A CONTROLLED RELEASE AMOXICILLIN FORMULATION
Authors:
- A ARANCIBIAAAA ARANCIBIA
- G GONZALEZGGG GONZALEZ
- A ICARTEAIA ICARTE
- M ARANCIBIAMAM ARANCIBIA
- P ARANCIBIAPAP ARANCIBIA
- 1 February 1987
- journal article
- research article
- Vol. 25 (2) , 97-100
Abstract
The pharmacokinetics and bioavailability of an in vitro controlled release amoxicillin formulation were studied in nine healthy volunteers, in comparison with an intravenous injection and a conventional tablet. The experiment was designed in a crossover fashion. The volunteers received the three formulations on separate occasions. The antibiotic was measured in plasma using a microbiological method. The absolute bioavailability of the two solid dosage forms was estimated comparing non-compartmental parameters. The results indicated that there was no correlation between the in vitro dissolution rate and the pharmacokinetic behavior in the body.Keywords
This publication has 3 references indexed in Scilit:
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