Análisis comparativo de la proteína C reactiva frente a la procalcitonina en la predicción de infecciones respiratorias bacterianas en adultos

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Abstract
This review article compares the diagnostic and prognostic performance of C-reactive protein (CRP) and procalcitonin (PCT) in detecting bacterial respiratory infections in adults. Evidence published between 2004 and 2025 was analyzed, including observational studies, clinical trials, and meta-analyses. Findings indicate that CRP shows higher sensitivity, whereas PCT demonstrates superior specificity and faster kinetic response to the onset and resolution of infection. The combined use of both biomarkers emerges as a balanced strategy to enhance diagnostic accuracy, optimize antibiotic use, and support antimicrobial stewardship programs. Clinical implications, methodological limitations, and future research directions are discussed, emphasizing the need for standardized diagnostic protocols and cost-effectiveness studies.

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