Diethylbenzene inhalation‐induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potentials in rats
Authors:
- 1 October 1992
- journal article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 12 (5) , 335-342
Abstract
Motor and sensory conduction velocities (MCV and SCV), amplitude of the sensory action potential (ASAP) of the tail nerve and parameters of brainstem auditory evoked potentials (BAEP) were studied in male Sprague‐Dawley rats after prolonged inhalation exposure to a commercial isomer mixture of diethylbenzene (DEB mixture) containing 6% 1, 2‐DEB. The MCV, SCV and ASAP were studied in one control group (10 rats) and three groups of 12 rats exposed to 500, 700 or 900 ppm DEB mixture for 6 h daily, 5 days per week, for 18 weeks. Rats used for recording BAEP (one control group and two other groups of 15 rats) were exposed to 600 and 800 ppm DEB mixture. The exposure time was the same. Rats exposed to DEB mixture exhibited a time‐ and concentration‐dependent decrease in MCV, SCV and ASAP and a time‐ and concentration‐dependent increase of both the peak latencies of all BAEP components and the interpeak (I–V) differences.Keywords
This publication has 11 references indexed in Scilit:
- Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene‐treated ratsJournal of Applied Toxicology, 1992
- Diethylbenzene‐induced sensorimotor neuropathy in ratsJournal of Applied Toxicology, 1990
- The influence of simultaneous exposure to carbon disulfide and hydrogen sulfide on the peripheral nerve toxicity and metabolism of carbon disulfide in ratsToxicology Letters, 1986
- Electrophysiologic deficits in peripheral nerve as a discriminator of early hexacarbon neurotoxicityJournal of Toxicology and Environmental Health, 1984
- Carbon Disulfide Neuropathy in Rats. A Morphological and Ultrastructural Study of Degeneration and RegenerationClinical Toxicology, 1981
- The Enlarging View of Hexacarbon NeurotoxicityCRC Critical Reviews in Toxicology, 1980
- 50 ppm MnBK subclinical neuropathy in ratsCellular and Molecular Life Sciences, 1979
- Conduction velocity in the peripheral nerves of rats with chronic carbon disulphide neuropathy.Occupational and Environmental Medicine, 1979
- An experimental study on the neurotoxicity of n-hexane metabolites: Hexanol-1 and hexanol-2Toxicology and Applied Pharmacology, 1978
- Electrophysiological studies on rabbits in long-term exposure to carbon disulfide.Scandinavian Journal of Work, Environment & Health, 1975