Association of GUCY2C Expression in Lymph Nodes With Time to Recurrence and Disease-Free Survival in pN0 Colorectal Cancer

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Abstract
Metastasis of tumor cells to regional lymph nodes is the single most important prognostic factor in patients with colorectal cancer.1,2 Recurrence rates increase from approximately 25% in patients with lymph nodes free of tumor cells by histopathology (pN0) to approximately 50% in patients with 4 or more lymph nodes harboring metastases.3,4 Adjuvant chemotherapy improves disease-free and overall survival in patients with histopathologically evident lymph node metastases, but its role in patients with pN0 colorectal cancer remains unclear.5-9

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