- 31 July 2020
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 59 (48) , 21377-21381
Abstract
The biological applications of germylenes remain unrealised owing to their unstable nature. We report the isolation of air‐, water‐, and culture‐medium‐stable germylene DPMGeOH (3; DPM=dipyrromethene ligand) and its potential biological application. Compound 3 exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound 3 on normal epithelial cells is minimal and is similar to that of the currently used anticancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low‐valent main‐group chemistry.Keywords
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Funding Information
- Anusandhan National Research Foundation (EMR/2017/005519, SR/FST/CSII-027/2014)
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