Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils

This publication has 29 references indexed in Scilit:

• Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: Discovery of MK-5286
  Bioorganic & Medicinal Chemistry Letters, 2010
• The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor
  ACS Medicinal Chemistry Letters, 2010
• 5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)—A potent FLAP inhibitor
  Bioorganic & Medicinal Chemistry Letters, 2010
• 5-Lipoxygenase-Activating Protein Inhibitors: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103)
  Journal of Medicinal Chemistry, 2009
• Leukotrienes
  New England Journal of Medicine, 2007
• 5-Lipoxygenase: regulation of expression and enzyme activity
  Trends in Biochemical Sciences, 2007
• Therapeutic options for 5-lipoxygenase inhibitors
  Pharmacology & Therapeutics, 2006
• 5-Lipoxygenase and FLAP
  Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
• Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
  Science, 2001
• Inhibitors of 5-lipoxygenase: a therapeutic potential yet to be fully realized?
  European Journal of Medicinal Chemistry, 1999