Detection of activated KRAS from cancer patient peripheral blood using a weighted enzymatic chip array
Open Access
- 26 May 2014
- journal article
- research article
- Published by Springer Nature in Journal of Translational Medicine
- Vol. 12 (1) , 147
Abstract
The KRAS oncogene was one of the earliest discoveries of genetic alterations in colorectal and lung cancers. Moreover, KRAS somatic mutations might be used for predicting the efficiency of anti-EGFR therapeutic drugs. The purpose of this research was to improve Activating KRAS Detection Chip by using a weighted enzymatic chip array (WEnCA) platform to detect activated KRAS mutations status in the peripheral blood of non-small-cell lung cancer (NSCLC) and colorectal cancer (CRC) patients in Taiwan.Keywords
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