The Emerging Mechanisms and Therapeutic Potentials of Dendritic Cells in NSCLC
Open Access
- 1 April 2025
- journal article
- review article
- Published by Taylor & Francis in Journal of Inflammation Research
- Vol. ume 18, 5061-5076
Abstract
Non-small-cell lung cancer (NSCLC) is the predominant subtype of lung cancer. Despite the demonstrated effectiveness of established treatments such as radiotherapy, chemotherapy, and immunotherapy, the prognosis for patients with advanced NSCLC remains poor. Dendritic cells (DCs), the most potent antigen-presenting cells (APCs), play a crucial role in the tumor microenvironment (TME) of NSCLC. This review explores the classification and biological functions of DCs, highlighting the specific molecular pathways and external factors that influence their maturation and function in NSCLC, which is novel in this review. Moreover, we discuss the potential therapeutic applications of DCs in the management of NSCLC, presenting novel possibilities for future treatments.Keywords
This publication has 143 references indexed in Scilit:
- MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancerOncogene, 2003
- Dendritic Cell Function in Vivo during the Steady State: A Role in Peripheral ToleranceAnnals of the New York Academy of Sciences, 2003
- Milestones in the Research on Skin Epidermal Langerhans/Dendritic Cells (LCs/DCs) from the Discovery of Paul Langerhans 1868–1989Virus Genes, 2003
- Mature dendritic cells make clusters with T cells in the invasive margin of colorectal carcinomaThe Journal of Pathology, 2001
- Interactions Between Dendritic Cells and Cytokine-Induced Killer Cells Lead to an Activation of Both PopulationsJournal of Immunotherapy, 2001
- Immunobiology of Dendritic CellsAnnual Review of Immunology, 2000
- Expression of CD86 on human marrow CD34(+) cells identifies immunocompetent committed precursors of macrophages and dendritic cells.1998
- Vascular Endothelial Growth Factor Affects Dendritic Cell Maturation Through the Inhibition of Nuclear Factor-κB Activation in Hemopoietic Progenitor CellsThe Journal of Immunology, 1998
- Production of interleukin-10 by human bronchogenic carcinoma.1994
- IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICEJournal of Experimental Medicine, 1973