Phosphinylalkylation of Indoles and Anilines Enabled by Electron-Donor–Acceptor (EDA) Complex Photoexcitation
- 6 March 2026
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 91 (11) , 4009-4020
Abstract
Visible light-mediated, multicomponent, regioselective phosphinylalkylation of indoles with readily available carbonyl compounds and diaryl phosphine oxides at ambient temperature is demonstrated. The strategy presented here is also effective with anilines. Key to this transformation is the electron-donor-acceptor (EDA) complex formation between the in situ generated (vinylogous) iminium intermediate and secondary phosphine oxides. Mechanistic studies supported the EDA complex-enabled radical pathway.Keywords
Funding Information
- Indian Institute of Technology Kanpur
- Anusandhan National Research Foundation (CRG/2022/000689)
- Ministry of Education, India
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