Eco‐Friendly Amide Synthesis Using a Metal and Halogen‐Free Deep Eutectic Solvent
- 21 August 2026
- journal article
- research article
- Published by Wiley in Chemistry – An Asian Journal
- Vol. 21 (16) , e70958
Abstract
A halogen‐ and metal‐free deep eutectic solvent (DES) consisting of choline hydroxide (ChOH) and urea (1:2) was employed as a green, reusable, and cost‐effective medium for the one‐pot synthesis of amide derivatives from aldehydes and hydroxylamines. The DES served simultaneously as solvent and catalyst, enabling the efficient formation of a wide variety of amides. The protocol afforded biologically and medicinally relevant compounds, including nicotinamide and bebenil, in excellent yields under mild conditions.Keywords
Funding Information
- Anusandhan National Research Foundation (CRG/2022/001941)
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