Formulation, Pharmacological Evaluation, and Efficacy Studies of Occidiofungin, a Novel Antifungal
Authors:
- 17 November 2020
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 64 (12)
Abstract
Occidiofungin is a nonribosomally synthesized cyclic lipopeptide that possesses broad-spectrum antifungal properties at submicromolar concentrations. This report explores multiple routes of administration and formulations of occidiofungin, as well as its toxicity in mice. Further, infection studies were performed in mice to assess the application of occidiofungin for treating systemic and intravaginal yeast infections. Formulations for intravenous and intravaginal administration of occidiofungin were prepared.Keywords
Funding Information
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R41AI131792-01, 2R42AI131792-02A1)
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