Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample
Open Access
- 23 September 2008
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 115 (11) , 1587-1589
Abstract
The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension “word reading”, the core phenotype in the study of Harold et al., which may be considered as supportive evidence.Keywords
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