FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis
Open Access
- 27 February 2018
- journal article
- research article
- Published by Springer Nature in Scientific Reports
- Vol. 8 (1) , 1-9
Abstract
Forkhead box P3 (FoxP3)+ regulatory T cells (Treg) are powerful mediators of immune regulation and immune homeostasis. In humans, Tregs are a heterogeneous population expressing surface markers which define phenotypically and functionally distinct subsets. Moreover, it is now clear that intracellular staining for FoxP3 does not unequivocally identify “true” suppressor cells, since several FoxP3 isoforms exist, and different reagents for FoxP3 detection are available. Here, we propose a strategy to identify potentially functional and suppressive Treg cells in an autoimmune disease like multiple sclerosis, and we suggest that in patients affected by this disease these cells are both reduced in number and functionally exhausted.Keywords
This publication has 44 references indexed in Scilit:
- Selection of regulatory T cells in the thymusNature Reviews Immunology, 2012
- FOXP3+ regulatory T cells in the human immune systemNature Reviews Immunology, 2010
- Regulatory T cells: roles of T cell receptor for their development and functionSeminars in Immunopathology, 2010
- Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription FactorImmunity, 2009
- Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and PeripheryImmunity, 2008
- Splice variants of human FOXP3 are functional inhibitors of human CD4+ T‐cell activationImmunology, 2006
- The role of 2 FOXP3 isoforms in the generation of human CD4+ TregsJournal of Clinical Investigation, 2005
- X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfyNature Genetics, 2001
- The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Nature Genetics, 2001
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseNature Genetics, 2001