ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium
Authors:
Open Access
- 1 January 2024
- journal article
- research article
- Published by Ivyspring International Publisher in Theranostics
- Vol. 14 (15) , 5762-5777
Abstract
Rationale: Tunnel nanotube (TNT)-mediated mitochondrial transport is crucial for the development and maintenance of multicellular organisms. Despite numerous studies highlighting the significance of this process in both physiological and pathological contexts, knowledge of the underlying mechanisms is still limited. This research focused on the role of the ROCK inhibitor Y-27632 in modulating TNT formation and mitochondrial transport in retinal pigment epithelial (RPE) cells.Keywords
This publication has 56 references indexed in Scilit:
- Intercellular communication: diverse structures for exchange of genetic informationNature Reviews Molecular Cell Biology, 2012
- Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling NanotubesPLOS ONE, 2012
- Wiring through tunneling nanotubes – from electrical signals to organelle transferJournal of Cell Science, 2012
- Mitochondria: In Sickness and in HealthCell, 2012
- Control of mitochondrial transport and localization in neuronsTrends in Cell Biology, 2010
- Mitochondria on the moveTrends in Cell Biology, 2007
- Mitochondrial transfer between cells can rescue aerobic respirationProceedings of the National Academy of Sciences, 2006
- Nanotubular Highways for Intercellular Organelle TransportScience, 2004
- Rapid Microtubule-dependent Induction of Neurite-like Extensions in NIH 3T3 Fibroblasts by Inhibition of ROCK and CblMolecular Biology of the Cell, 2003
- Signalling and crosstalk of Rho GTPases in mediating axon guidanceNature Cell Biology, 2002