Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea

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Abstract
Sponges of the genus Neopetrosia are known for the production of a large diversity of bioactive metabolites. Contignasterines A (1) and B (2) were isolated as major metabolites of the sponge Neopetrosia cf. rava collected in the Bismarck Sea along with the known and highly bioactive steroid contignasterol (3) possessing a similar oxidized aglycone. Contignasterines are characterized by the presence of a 2-aminoimidazole branched on the side-chains of the oxidized steroid, and 1 also contains an unusual phosphate group at C-7. The anti-inflammatory activities of these compounds were investigated and revealed that all three compounds inhibited the production of pro-inflammatory mediators.
Funding Information
  • Fondation Veolia Environnement
  • Fondation Tara Oc?an
  • Prince Albert II of Monaco Foundation
  • Universidad de Ja?n
  • Universit? C?te d?Azur
  • United Nations Educational, Scientific and Cultural Organization
  • Fonds Fran?ais pour l'Environnement Mondial
  • Walt Disney Company
  • R?gion Bretagne
  • Interreg (EAPA_0017/2022)
  • HORIZON EUROPE Food, Bioeconomy, Natural Resources, Agriculture and Environment (101135438)
  • Agence Nationale de la Recherche
  • Institut National de la Sant? et de la Recherche M?dicale
  • Ministerio de Ciencia, Innovaci?n y Universidades (CPP 2021-008447, PID 2020-11262RB-C21)
  • H2020 Marie Sklodowska-Curie Actions (101119901- BIOTOXDoc)
  • ?cole Pratique des Hautes ?tudes, Universit? de Recherche Paris Sciences et Lettres
  • Centre National de la Recherche Scientifique
  • Universit? de Recherche Paris Sciences et Lettres
  • NextGenerationEU
  • Commissariat ? l'?nergie Atomique et aux ?nergies Alternatives
  • Conseller?a de Cultura, Educaci?n e Ordenaci?n Universitaria, Xunta de Galicia (ED431C 2021/01)
  • Etienne Bourgois
  • L?Or?al
  • Serge Ferrari
  • Agn?s b.
  • France Collectivit?s
  • BillerudKorsnäs
  • Genoscope - National Center of Sequencing
  • Kankyo Station
  • Lorient Agglomeration
  • Amerisource Bergen Company
  • CSM
  • Biotherm

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