Physical Activity and Rapid Decline in Kidney Function Among Older Adults

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Abstract
Chronic kidney disease is one of the fastest growing health conditions in older people. Approximately 30% of individuals older than 70 years have chronic kidney disease, defined by an estimated glomerular filtration rate (eGFR) lower than 60 mL/min/1.73 m2, which is less than half of normal for a young, healthy adult.1 Kidney dysfunction is a major risk factor for cardiovascular events and mortality across multiple populations. In older individuals, a lower eGFR, as estimated by serumcystatin C levels, is linearly related to the risk of cardiovascular events, premature death, and a decline in functional status.2-4 The age-associated decline in kidney function is highly variable5,6; identifying modifiable factors that could preserve kidney function later in life could have a substantial public health impact.

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