Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
Open Access
- 29 April 2014
- journal article
- Published by Taylor & Francis in OncoImmunology
- Vol. 3 (5) , e28783
Abstract
Galectins released by tumor cells and macrophages can bind surface glycoproteins of tumor-infiltrating lymphocytes (TILs), forming glycoprotein-galectin lattices with immunosuppressive activities. Specifically, TILs covered by galectin-3 are unable to secrete cytokines after stimulation. Treating TILs ex vivo with galectin antagonists for a few hours boosts their functions. Several galectin antagonists are currently available for clinical trials.Keywords
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