Spike timing–dependent long-term depression requires presynaptic NMDA receptors
- 30 May 2008
- journal article
- Published by Springer Nature in Nature Neuroscience
- Vol. 11 (7) , 744-745
Abstract
NMDA receptors are necessary for both synaptic potentiation and depression, but the precise location of these receptors has not been established. By loading MK-801 into pre- or postsynaptic neurons during paired recordings of synaptically connected layer 4 and layer 2/3 neurons in mouse barrel cortex, we found that synaptic potentiation requires postsynaptic, but not presynaptic, NMDA receptors, whereas synaptic depression requires presynaptic, but not postsynaptic, NMDA receptors.Keywords
This publication has 15 references indexed in Scilit:
- Spike Timing-Dependent Plasticity: From Synapse to PerceptionPhysiological Reviews, 2006
- Map Plasticity in Somatosensory CortexScience, 2005
- Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term PotentiationJournal of Neuroscience, 2005
- Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term DepressionJournal of Neuroscience, 2004
- Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic PlasticityScience, 2004
- Neocortical LTD via Coincident Activation of Presynaptic NMDA and Cannabinoid ReceptorsNeuron, 2003
- Timing-Based LTP and LTD at Vertical Inputs to Layer II/III Pyramidal Cells in Rat Barrel CortexNeuron, 2000
- Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell TypeThe Journal of Neuroscience, 1998
- Long‐term synaptic plasticity between pairs of individual CA3 pyramidal cells in rat hippocampal slice culturesThe Journal of Physiology, 1998
- Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPsScience, 1997