Multiomics analysis reveals that senescent CXCL16+ macrophages promote lung adenocarcinoma progression through TGF-β signalling

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Open Access

2 February 2026

journal article
research article
Published by Springer Nature in Journal of Translational Medicine

Abstract

Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer and remains a leading cause of cancer-related mortality worldwide. Althou

Keywords

This publication has 40 references indexed in Scilit:

Targeted enhancement of antigen cross-presentation capability of M2-like tumor-associated macrophages to boost glioblastoma immunotherapy
Biomaterials, 2025
Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing
Advanced Science, 2025
Activation of transforming growth factor beta 1 through integrin alpha V beta 6 and its molecular insights into cancer progression, and future directions
International Journal of Biological Macromolecules, 2025
From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis
Cytokine & Growth Factor Reviews, 2025
An emerging paradigm of CXCL16 involvement in cancer progression
Cytokine & Growth Factor Reviews, 2025
Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF
International Immunopharmacology, 2024
Spatial transcriptomic revealed intratumor heterogeneity and cancer stem cell enrichment in colorectal cancer metastasis
Cancer Letters, 2024
TGF-β-induced lncRNA TBUR1 promotes EMT and metastasis in lung adenocarcinoma via hnRNPC-mediated GRB2 mRNA stabilization
Cancer Letters, 2024
Tumor-associated macrophages promote cisplatin resistance in ovarian cancer cells by enhancing WTAP-mediated N6-methyladenosine RNA methylation via the CXCL16/CXCR6 axis
Cancer Chemotherapy and Pharmacology, 2023
Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner
Cell Reports, 2023