Automated robotic platforms in design and development of formulations
Open Access
- 23 February 2021
- journal article
- research article
- Published by Wiley in AIChE Journal
- Vol. 67 (5) , e17248
Abstract
Product design for formulations is an active and challenging area of research. The new challenges of a fast‐paced market, products of increasing complexity, and practical translation of sustainability paradigms require to re‐examine the existing theoretical frameworks to include the advantages deriving from the new reality of digitalization of business and research. In this work, we review the existing approaches, clearly stating the role of automation and machine‐learning‐guided optimization in the broader framework. Moving from this, we review the state of the art of automated hardware and software for formulated product design, and identify the open challenges for future research. Perspectives are given on the emerging fields of automated discovery, scale‐up, and multistage optimization, and a unitary picture of the existing connections is provided, in the general context of a completely digital R&D workflow.Keywords
Funding Information
- Engineering and Physical Sciences Research Council (EP/R009902/1)
- National Research Foundation
This publication has 164 references indexed in Scilit:
- Rapid Determination of Reaction Kinetics with an Automated Microfluidic SystemOrganic Process Research & Development, 2011
- Automated Synthesis of a 184-Member Library of Thiadiazepan-1,1-dioxide-4-onesACS Combinatorial Science, 2011
- Formulation Development of Antibodies Using Robotic System and High-Throughput Laboratory (HTL)Journal of Pharmaceutical Sciences, 2010
- Solution prepolymerization as a new route for preparing aliphatic polyurethane prepolymers using high‐throughput experimentationJournal of Polymer Science Part A: Polymer Chemistry, 2009
- Scale-up of batch kinetic modelsAnalytica Chimica Acta, 2007
- SynCar: An Approach to Automated SynthesisJournal of Combinatorial Chemistry, 2005
- Design of alternative refrigerants via global optimizationAIChE Journal, 2003
- Description of several chemical structure file formats used by computer programs developed at Molecular Design LimitedJournal of Chemical Information and Computer Sciences, 1992
- Minimax and maximin distance designsJournal of Statistical Planning and Inference, 1990
- SAFT: Equation-of-state solution model for associating fluidsFluid Phase Equilibria, 1989