c-Mpl ligand is a humoral regulator of megakaryocytopoiesis
Authors:
- [Ccedil][C[Ccedil]
- Oise WendlingOWOise Wendling
- Eugene MaraskovskyEMEugene Maraskovsky
- Najet DebiliNDNajet Debili
- Christina FlorindoCFChristina Florindo
- Mark TeepeMTMark Teepe
- Monique TiteuxMTMonique Titeux
- Nassia MethiaNMNassia Methia
- Janine Breton-GoriusJBJanine Breton-Gorius
- David CosmanDCDavid Cosman
- William VainchenkerWVWilliam Vainchenker
- 1 June 1994
- journal article
- Published by Springer Nature in Nature
- Vol. 369 (6481) , 571-574
Abstract
Megakaryocytopoiesis is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocyte progenitors, and the second, thrombopoietin, is a megakaryocyte maturation factor. Neither of these factors has been fully characterized. The proto-oncogene c-mpl, an orphan member of the haematopoietin receptor family, is specifically involved in megakaryocyte regulation. Here we present evidence that the c-mpl-encoded receptor binds a ligand (c-Mpl ligand) which is a humoral factor implicated in platelet homeostasis. Our results suggest that c-Mpl ligand, thrombopoietin and MK-CSF might be the same molecule.Keywords
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