Organelle Communication: Joined in Sickness and in Health
- 1 May 2023
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 38 (3) , 101-109
Abstract
Organelles are membrane-lined structures that compartmentalize subcellular biochemical functions. Therefore, interorganelle communication is crucial for cellular responses that require the coordination of such functions. Multiple principles govern interorganelle interactions, which arise from the complex nature of organelles: position, multilingualism, continuity, heterogeneity, proximity, and bidirectionality, among others. Given their importance, alterations in organelle communication have been linked to many diseases. Among the different types of contacts, endoplasmic reticulum mitochondria interactions are the best known; however, mounting evidence indicates that other organelles also have something to say in the pathophysiological conversation.Keywords
Funding Information
- Agencia Nacional de Investigación y Desarrollo (FONDECYT 11201267)
- Agencia Nacional de Investigación y Desarrollo (FONDECYT 3190546)
- Agencia Nacional de Investigación y Desarrollo (FONDECYT 1211329)
- Agencia Nacional de Investigación y Desarrollo (PIA-ACT 172066)
- Agencia Nacional de Investigación y Desarrollo (FONDECYT 1200490)
- Agencia Nacional de Investigación y Desarrollo (FONDAP 15130011)
- Universidad de Chile (UI-006/19)
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