Some clarifications regarding moments of residence times with pharmacokinetic models
Author:
- 1 February 1987
- journal article
- research article
- Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 15 (1) , 75-92
Abstract
The stochastic formulation of linear kinetic models is elaborated in order to introduce some new concepts and help clarify the meaning and role of residence time moments. Certain conditional moments are introduced. Multicompartment and steady-state dosing within the stochastic context are considered. A general model-independent formula for steady state volume of distribution and a new concept of steady-state moments are presented. A technique for constructing a model of a given topology from its moments is also given.Keywords
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