Precision editing of cyclophilin A generates cyclosporine- and voclosporin-resistant cellular therapies
Authors:
- Holly WobmaHWHolly Wobma
- Francesca Alvarez-CalderonFAFrancesca Alvarez-Calderon
- Jiayi DongJDJiayi Dong
- Kayleigh OmdahlKOKayleigh Omdahl
- Xianliang RuiXRXianliang Rui
- Elisa J. Rojas PalatoEPElisa J. Rojas Palato
- Rene S. BermeaRBRene S. Bermea
- Alexandre AlbaneseAAAlexandre Albanese
- Franziska WachterFWFranziska Wachter
- Marlana WinschelMWMarlana Winschel
- Katherine A. MichaelisKMKatherine A. Michaelis
- William A. BurnsWBWilliam A. Burns
Open Access
- 20 April 2026
- journal article
- Published by Elsevier in Blood Immunology & Cellular Therapy
- Vol. 2 (2)
Abstract
No abstract availableAll Related Versions
Funding Information
- National Institute of Child Health and Human Development (K12HD052896)
- Lupus Research Alliance (P30-AR070253)
- Lupus Research Alliance (R01AR073201)
- Lupus Research Alliance (R01 HL11879)
- Lupus Research Alliance (R01AR075906)
- Lupus Research Alliance (R37 AI34495)
- Lupus Research Alliance (2P01 CA065493)
- National Institutes of Health (U19-AI051731)
- National Institutes of Health (P01-HL158504)
- National Institutes of Health (R01-HL095791)
- American Society for Transplantation and Cellular Therapy
- National Institute of Allergy and Infectious Diseases (T32AI007512-36)
This publication has 58 references indexed in Scilit:
- Clinical Pharmacokinetics and Pharmacodynamics of VoclosporinClinical Pharmacokinetics, 2023
- Update on the Efficacy and Safety Profile of Voclosporin: An Integrated Analysis of Clinical Trials in Lupus NephritisArthritis Care & Research, 2023
- Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cellsCellular and Molecular Life Sciences, 2022
- Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and International Society for Heart and Lung Transplantation: An executive summaryPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2022
- Function and evolution of the prototypic CD28ζ and 4-1BBζ chimeric antigen receptorsImmuno-Oncology and Technology, 2020
- Evidence for a Bidirectional Relationship between Cytomegalovirus Replication and acute Graft-versus-Host DiseaseTransplantation and Cellular Therapy, 2010
- Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive BehaviorNeuron, 2008
- Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ TranslocationImmunity, 2008
- Cyclophilin A Regulates TCR Signal Strength in CD4+ T Cells via a Proline-Directed Conformational Switch in ItkImmunity, 2004
- Active site mutants of human cyclophilin A separate peptidyl‐prolyl isomerase activity from cyclosporin A binding and calcineurin inhibitionProtein Science, 1992