PLATELET-DERIVED GROWTH FACTOR, TRANSFORMING GROWTH FACTOR-β, AND CONNECTIVE TISSUE GROWTH FACTOR IN A PORCINE BRONCHIAL MODEL OF OBLITERATIVE BRONCHIOLITIS

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Abstract
The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-β, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF-A, PDGF receptors α and β, and TGF-β expression occurred in allografts, whereas PDGF-B and CTGF expression was similar in allo- and autografts. Imatinib modified the inflammatory responses and expression patterns of PDGF-A and PDGF receptors. This study further confirms PDGF and TGF-β as mediators of OB and supports the concept of the importance of the pathways signaled through PDGF receptors in post-transplant OB.

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