TCR Repertoire Changes during TIL Expansion: Clonal Selection or Drifting?
Authors:
- 14 August 2020
- journal article
- editorial
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 26 (16) , 4177-4179
Abstract
T-cell receptor β analysis can be exploited to monitor changes in the clonotypic composition of tumor-infiltrating lymphocyte (TIL) during ex vivo expansion in IL2. Oligoclonal TILs are often outgrown by infrequent clonotypes with greater proliferative capacity, and this could impact the antitumor reactivity of the expanded TILs. See related article by Poschke et al., p. xxxKeywords
Funding Information
- Government of Catalonia | Agència de Gestió d'Ajuts Universitaris i de Recerca (2018FI_B00946)
- MEC | Instituto de Salud Carlos III (MS15,CP15/00058; P17/01085)
- Fundación Científica Asociación Española Contra el Cáncer (LABAE16021PORT)
- Fundación BBVA (CAIMI)
- CELLEX Foundation
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