Synthetic Methodology-driven Chemical Protein Modifications
Authors:
- 5 November 2019
- journal article
- review article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 48 (11) , 1421-1432
Abstract
The installation of novel and artificial functions to proteins through modifications of their chemical structure is an emerging research field covering chemistry, biology, and medicine. Because the reactions must proceed with high chemo- and regio-selectivity under mild conditions in aqueous solvents, developing chemical methods for precise protein modifications affording homogenous products is a great challenge in organic synthesis. Here we review selected recent examples of synthetically-inspiring chemical protein modifications. The chemistry discussed here will lead to novel methodologies for the efficient synthesis of broad range of organic molecules.Keywords
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