Effects and mechanisms of berberine-loaded tetrahedral framework nucleic acids on osteoporosis

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Abstract
A new nanocomplex T-BBR was synthesized by carrying BBR with tFNAs. Compared with BBR, T-BBR showed better osteogenic and anti-osteoporosis abilities in both in vivo and in vitro experiments through the Wnt/β-catenin signaling pathway.
Funding Information
  • National Natural Science Foundation of China (82372447)
  • National Natural Science Foundation of China (82202747)
  • Science and Technology Department of Tibet Autonomous Region (XZ202201ZD0001G)
  • Science and Technology Department of Tibet Autonomous Region (XZ202303ZY0007G)
  • Sichuan University (ZYJC21026)
  • Sichuan University (ZYJC21077)
  • Sichuan University (2024HXBH160)
  • Sichuan University (2024HXBH160)

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