Background

Authors:
Publisher website
Google Scholar
Abstract
Surgical technique in pancreatic cancer has seen significant developments. Thirty years ago, pancreaticoduodenectomy was associated with a postoperative mortality of 20–30%, including reports from large institutions, whereas the acceptable standard today is a few percent [ 1 x [1] Andersen, H.B., Baden, H., Brahe, N.E., and Burcharth, F. Pancreaticoduodenectomy for periampullary adenocarcinoma. J Am Coll Surg. 1994; 179: 545–552 PubMed | Google Scholar See all References , 2 x [2] Fernandez-del Castillo, C., Rattner, D.W., and Warshaw, A.L. Standards for pancreatic resection in the 1990s. Arch Surg. 1995; 130: 295–299 Crossref | PubMed | Scopus (443) | Google Scholar See all References , 3 x [3] Delcore, R., Rodriguez, F.J., Forster, J., Hemreck, A.S., and Thomas, J.H. Significance of lymph node metastases in patients with pancreatic cancer undergoing curative resection. Am J Surg. 1996; 172: 463–468 Abstract | Full Text PDF | PubMed | Scopus (84) | Google Scholar See all References , 4 x [4] Gouma, D.J., van Geenen, R.C., van Gulik, T.M., de Haan, R.J., de Wit, L.T., and Busch, O.R. Rates of complications and death after pancreaticoduodenectomy: risk factors and the impact of hospital volume. Ann Surg. 2000; 232: 786–795 Crossref | PubMed | Scopus (568) | Google Scholar See all References , 5 x [5] Sohn, T.A., Yeo, C.J., Cameron, J.L., Koniaris, L., Kaushal, S., and Abrams, R.A. Resected adenocarcinoma of the pancreas – 616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg. 2000; 4: 567–579 Crossref | PubMed | Scopus (1099) | Google Scholar See all References , 6 x [6] Richter, A., Niedergethmann, M., Sturm, J.W., Lorenz, D., Post, S., and Trede, M. Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience. World J Surg. 2003; 27: 324–329 Crossref | PubMed | Scopus (301) | Google Scholar See all References , 7 x [7] Wagner, M., Redaelli, C., Lietz, M., Seiler, C.A., Friess, H., and Buchler, M.W. Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg. 2004; 91: 586–594 Crossref | PubMed | Scopus (564) | Google Scholar See all References ]. Although long-term survival may not have improved to the same extent, development and sophistication of imaging modalities such as sonography, computed tomography (CT) and magnetic resonance (MR) scanning have made diagnosis and especially accurate staging easier, which means that malignancies limited to the pancreas may be selected for surgery. Several reports indicate improved survival after pancreaticoduodenectomy with curative intent, with median and 5-year survival figures in the range of 11–20 months and 7–25%, respectively [ 1 x [1] Andersen, H.B., Baden, H., Brahe, N.E., and Burcharth, F. Pancreaticoduodenectomy for periampullary adenocarcinoma. J Am Coll Surg. 1994; 179: 545–552 PubMed | Google Scholar See all References , 3 x [3] Delcore, R., Rodriguez, F.J., Forster, J., Hemreck, A.S., and Thomas, J.H. Significance of lymph node metastases in patients with pancreatic cancer undergoing curative resection. Am J Surg. 1996; 172: 463–468 Abstract | Full Text PDF | PubMed | Scopus (84) | Google Scholar See all References , 4 x [4] Gouma, D.J., van Geenen, R.C., van Gulik, T.M., de Haan, R.J., de Wit, L.T., and Busch, O.R. Rates of complications and death after pancreaticoduodenectomy: risk factors and the impact of hospital volume. Ann Surg. 2000; 232: 786–795 Crossref | PubMed | Scopus (568) | Google Scholar See all References , 5 x [5] Sohn, T.A., Yeo, C.J., Cameron, J.L., Koniaris, L., Kaushal, S., and Abrams, R.A. Resected adenocarcinoma of the pancreas – 616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg. 2000; 4: 567–579 Crossref | PubMed | Scopus (1099) | Google Scholar See all References , 6 x [6] Richter, A., Niedergethmann, M., Sturm, J.W., Lorenz, D., Post, S., and Trede, M. Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience. World J Surg. 2003; 27: 324–329 Crossref | PubMed | Scopus (301) | Google Scholar See all References , 7 x [7] Wagner, M., Redaelli, C., Lietz, M., Seiler, C.A., Friess, H., and Buchler, M.W. Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg. 2004; 91: 586–594 Crossref | PubMed | Scopus (564) | Google Scholar See all References ].

This publication has 29 references indexed in Scilit: