Synergism and Antagonism of Lenalidomide–(β-D-Ribofuranose 2',3'-phosphodiester)–Paclitaxel as a Selective Anticancer Codrug

Authors:
  • APAvijit Panja
    Avijit Panja
  • STShwu Chen Tsay
    Shwu Chen Tsay
  • WHWen-Chieh Huang
    Wen-Chieh Huang
  • TPTapan Kumar Pradhan
    Tapan Kumar Pradhan
  • CYChen-Sheng Yeh
    Chen-Sheng Yeh
  • WSWu Chou Su
    Wu Chou Su
  • LYLi Xing Yang
    Li Xing Yang
  • DSDar Bin Shieh
    Dar Bin Shieh
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Abstract
A novel codrug 1 is designed through the covalent conjugation of lenalidomide (2, an immunomodulatory agent) and paclitaxel (3, an anticancer drug) via...