Immune thrombocytopenia more than a year after allogeneic marrow transplantation due to antibodies against donor platelets with anti‐PIA1 specificity: evidence for a host‐derived immune reaction

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Abstract
Summary We report on a male patient transplanted from his HLA‐matched sister for Ph1‐chromosome positive chronic myelogenous leukaemia who developed immune thrombocytopenia more than 1 year after transplantation. The platelet antibody reacted with the platelet specific antigen PIA1 on donor platelets, and also on recipient platelets after engraftment. A presumed host‐versus‐donor induced thrombocytopenia was supported by Southern blot analysis using a Y‐chromosome specific probe demonstrating residual hostorigin cells in the patient's excised spleen.

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