The role of anti-Müllerian hormone assessment in assisted reproductive technology outcome

Authors:
  • BMBenWillem Mol
    BenWillem Mol
  • MDMadeleine Dólleman
    Madeleine Dólleman
  • BFBart C Fauser
    Bart C Fauser
  • FBFrank Jm Broekmans
    Frank Jm Broekmans
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Abstract
The purpose of this study is to summarize the role of anti-Müllerian hormone (AMH) in assisted reproductive technology (ART) treatment. AMH is a good marker in the prediction of ovarian response to controlled ovarian hyperstimulation. In clinical practice, this means that AMH may be used for identifying poor or excessive responders. So far, studies show that AMH is not a good predictor for the occurrence of pregnancy after ART treatment. Therefore, routine screening for a poor ovarian reserve status using AMH is not to be advocated. Still, ovarian response prediction using AMH may open ways for patient-tailored stimulation protocols in order to reduce cancellations for excessive response, possibly improve pregnancy prospects and reduce costs. AMH is able to predict extremes in ovarian response to controlled ovarian hyperstimulation but cannot predict pregnancy after ART treatment. Its future clinical role may be in the individualization of ART stimulation protocols.

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