SWI3B and HDA6 interact and are required for transposon silencing in Arabidopsis

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Abstract
Summary: Although the interplay of covalent histone acetylation/deacetylation and ATP‐dependent chromatin remodelling is crucial for the regulation of chromatin structure and gene expression in eukaryotes, the underlying molecular mechanism in plants remains largely unclear. Here we show a direct interaction between Arabidopsis SWI3B, an essential subunit of the SWI/SNF chromatin‐remodelling complex, and the RPD3/HDA1‐type histone deacetylase HDA6 both in vitro and in vivo. Furthermore, SWI3B and HDA6 co‐repress the transcription of a subset of transposons. Both SWI3B and HDA6 maintain transposon silencing by decreasing histone H3 lysine 9 acetylation, but increasing histone H3 lysine 9 di‐methylation, DNA methylation and nucleosome occupancy. Our findings reveal that SWI3B and HDA6 may act in the same co‐repressor complex to maintain transposon silencing in Arabidopsis.
Funding Information
  • National Natural Science Foundation of China (31771366, 31371308)
  • Youth Innovation Promotion Association of the Chinese Academy of Sciences (2014319)
  • Ministry of Science and Technology, Taiwan (105‐2311‐B‐002‐012‐MY3, 107‐2313‐B‐002‐001)

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