Exploring the Relationship Between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects
Authors:
- Guillermo Efrén Villar-JuárezGuillermo Efrén Villar-Juárez
- Alma Delia Genis-MendozaAlma Delia Genis-Mendoza
- J. Nicolas I. Martínez-LópezJ. Nicolas I. Martínez-López
- Ana FresanAna Fresan
- Carlos Alfonso Tovilla-ZaráteCarlos Alfonso Tovilla-Zaráte
- Germán Alberto Nolasco-RosalesGermán Alberto Nolasco-Rosales
- Ghandy Isidro Juárez-De la CruzGhandy Isidro Juárez-De la Cruz
- Paola Mejía-OrtizPaola Mejía-Ortiz
- Marlen Gómez-MendiolaMarlen Gómez-Mendiola
- Isela Esther Juárez-RojopIsela Esther Juárez-Rojop
- Humberto NicoliniHumberto Nicolini
Preprint
- 5 September 2024
- preprint
- Published by MDPI AG in Preprints.org
Abstract
Emerging evidence suggests that patients suffering from COVID-19 may experience neurocognitive symptoms. Besides, other studies indicate a probable association between leukocyte telomere length (LTL) and neurocognitive changes in subjects with post-COVID-19 condition. Our study was designed to determine the correlation between telomere length and cognitive changes in subjects post-COVID-19. The study included 256 subjects, categorized based on SARS-CoV-2 infection from 2020 to 2023. On the other hand, those subjects who have a psychiatric diagnosis are considered. Besides, the MoCA and MMSE scales were applied. Telomere length was determined using a Polymerase Chain Reaction, and statistical analysis was employed ANOVA and X2 tests. We identified a decrease in LTL in individuals with post-COVID-19 conditions compared to those without SARS-CoV-2 infection (p≤0.05). However, no association was found between LTL and cognitive impairment in subjects post-COVID-19. The findings suggest that LTL is affected by SARS-CoV-2 infection. Nonetheless, this important finding requires further research by monitoring neurological changes in subjects with post-COVID condition.Keywords
All Related Versions
- Version 1, 2024-09-05, Preprints
- Published version: Biomedicines, 12 (10), 2296.