Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis

Authors:
  • EGENIGMA Clinical High Risk for Psychosis Working Group
    ENIGMA Clinical High Risk for Psychosis Working Group
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Abstract
The clinical high-risk (CHR) paradigm is a widely used framework to investigate mechanisms underlying psychosis vulnerability. Help-seeking individuals who do not meet diagnostic criteria for a psychotic disorder but typically present with subthreshold psychotic symptoms and accumulating risk factors are considered at CHR for developing psychosis.1 An estimated 18% to 20% of individuals at CHR develop a psychotic disorder within 2 years of identification,2 although conversion rates vary, likely due to heterogeneous recruitment and sampling strategies as well as interventions applied.3 However, despite decades of research, the nature of morphometrical differences associated with psychosis conversion remains largely unknown. Here, we aim to address this question by combining all available structural neuroimaging data in CHR to date in an attempt to better understand group differences associated with psychosis risk and conversion in this population.
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