Tumor Promotion by Phorbol Esters in Skin: Evidence for a Memory Effect
Authors:
- 1 April 1983
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 220 (4592) , 89-91
Abstract
By means of a two-stage promotion protocol in mouse epidermis with 12- O -tetradecanoylphorbol-13-acetate as first-stage promoter and 12- O -retinoylphorbol-13-acetate as second-stage promoter, the effects of the former that are critical and obligatory for tumor promotion were shown to be irreversible in nature for at least 8 weeks. The reversibility of tumor promotion was related to the second stage of promotion, reflecting the reversibility of epidermal hyperplasia induced by 12- O -tetradecanoylphorbol-13-acetate.Keywords
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