Preparation of optically active 6′-fluorocarbocyclic nucleosides utilising an enantiospecific enzyme-catalysed Baeyer–Villiger type oxidation

Authors:
  • MLMelissa S. Levitt
    Melissa S. Levitt
  • RNRoger F. Newton
    Roger F. Newton
  • SRStanley M. Roberts
    Stanley M. Roberts
  • AWAndrew J. Willetts
    Andrew J. Willetts

Abstract
Kinetic resolution of the racemic ketone (±)-(1) was achieved using Acinetobacter NCIB 9871: the optically active norbornanone was converted into the carbocyclic nucleosides (5) and (7).

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