Hypoventilation in Obstructive Lung Disease

Authors:
  • RMRichard Mountain
    Richard Mountain
  • CZClifford Zwillich
    Clifford Zwillich
  • JWJohn Weil
    John Weil
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Abstract
To determine the role of familial factors in the hypoventilation of chronic obstructive lung disease we measured chemical drives to breathe in normal offspring of two groups of patients with an equal degree of obstruction. One group of five patients had repeatedly normal arterial carbon dioxide tension (PaCO2), whereas PaCO2's were elevated in the other group of six. Two adult offspring of each patient were studied. Drives were measured as the ventilatory response to isocapnic hypoxia, and the slopes of the ventilation/PCO2 relation (the hypercapnic ventilatory response).

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