Compounds from Natural Sources as Protein Kinase Inhibitors
Open Access
- 12 November 2020
- journal article
- review article
- Published by MDPI AG in Biomolecules
- Vol. 10 (11) , 1546
Abstract
The advantage of natural compounds is their lower number of side-effects when compared to most synthetic substances. Therefore, over the past several decades, the interest in naturally occurring compounds is increasing in the search for new potent drugs. Natural compounds are playing an important role as a starting point when developing new selective compounds against different diseases. Protein kinases play a huge role in several diseases, like cancers, neurodegenerative diseases, microbial infections, or inflammations. In this review, we give a comprehensive view of natural compounds, which are/were the parent compounds in the development of more potent substances using computational analysis and SAR studies.Keywords
This publication has 224 references indexed in Scilit:
- Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2BMC Pharmacology and Toxicology, 2013
- mTOR Signaling in Growth Control and DiseaseCell, 2012
- Discovery and Assembly-Line Biosynthesis of the Lymphostin Pyrroloquinoline Alkaloid Family of mTOR Inhibitors in Salinispora BacteriaJournal of the American Chemical Society, 2011
- Cysteine Mapping in Conformationally Distinct Kinase Nucleotide Binding Sites: Application to the Design of Selective Covalent InhibitorsJournal of Medicinal Chemistry, 2011
- ACS Chemical Neuroscience Spotlight on CEP-1347ACS Chemical Neuroscience, 2010
- Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor BalanolJournal of Medicinal Chemistry, 2010
- Type-II Kinase Inhibitor Docking, Screening, and Profiling Using Modified Structures of Active Kinase StatesJournal of Medicinal Chemistry, 2008
- Protein kinase CK2 – A key suppressor of apoptosisAdvances in Enzyme Regulation, 2008
- Crystal structure of the Src family tyrosine kinase HckNature, 1997
- Metabolites of pyrenomycetes XIII: Structure of (+) hypothemycin, an antibiotic macrolide from Hypomyces trichothecoidesTetrahedron Letters, 1980