Point-of-Care Urine Tenofovir Drug-Level Feedback Counseling Improves Long-Term Pre-exposure Prophylaxis Adherence for US Men Who Have Sex With Men in Pilot RCT
Open Access
- 10 February 2026
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 82 (5) , e992-e995
Abstract
A remote, motivational interviewing–informed intervention using self-administered point-of-care urine tenofovir testing improved long-term pre-exposure prophylaxis (PrEP) adherence among young US men-who-have-sex-with-men in a pilot randomized trial. Participants increased hair tenofovir levels by 1–2 tablets weekly, with high feasibility and acceptability, supporting further implementation.Keywords
Funding Information
- National Institutes of Health (K23MH122286)
- National Institutes of Health (2R01AI143340)
This publication has 12 references indexed in Scilit:
- The impact of adherence counseling incorporating a point of care urine tenofovir assay on virologic suppression among individuals failing tenofovir-lamivudine-dolutegravir: A pre-post intervention studyInternational Journal of Infectious Diseases, 2024
- Trends in Oral and Injectable HIV Preexposure Prophylaxis Prescriptions in the US, 2013-2023JAMA, 2024
- Impact of a point-of-care urine tenofovir assay on adherence to HIV pre-exposure prophylaxis among women in Kenya: a randomised pilot trialThe Lancet HIV, 2024
- Point-of-care urine tenofovir test predicts future HIV preexposure prophylaxis discontinuation among young usersAIDS, 2024
- Urine point-of-care tenofovir test demonstrates strong predictive clinical and research utilityAIDS, 2023
- Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide‐based ARTDrug Testing and Analysis, 2021
- Brief Report: High Accuracy of a Real-Time Urine Antibody-Based Tenofovir Point-of-Care Test Compared With Laboratory-Based ELISA in Diverse PopulationsJAIDS Journal of Acquired Immune Deficiency Syndromes, 2020
- Development and validation of the first point-of-care assay to objectively monitor adherence to HIV treatment and prevention in real-time in routine settingsAIDS, 2020
- An HIV Preexposure Prophylaxis Demonstration Project and Safety Study for Young MSMJAIDS Journal of Acquired Immune Deficiency Syndromes, 2017
- Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort studyThe Lancet Infectious Diseases, 2014