Abstract
This study described the profile and trend of male mortality from external causes in three ecological clusters. This was a descriptive study of time series with data from the municipality of Campo Grande (CG), the state of Mato Grosso do Sul (MS), and Brazil, from 2010 to 2019. The numbers of deaths and inhabitants for each cluster were retrieved from DATASUS. From 2010 to 2014, the state of MS showed higher death rates from external causes, which came to be close to the rates in Brazil from 2015 to 2019. There was a general downward trend in mortality rates in the historical series, however, there was an increase in deaths from self-inflicted injuries and deaths of indigenous and yellow people, especially in CG. The psychosocial issues interrelated in the constitution of male vulnerabilities to external causes have to be deepened in further studies, as well as effective preventive actions have to be developed for the male population.

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