UPTAKE AND RELEASE OF NIPECOTIC ACID BY RAT BRAIN SLICES
Authors:
- 1 January 1976
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 26 (1) , 83-87
Abstract
—Nipecotic acid, a potent inhibitor of GABA uptake, is taken up by slices of rat cerebral cortex by a sodium‐dependent, ‘high affinity’ system (Km 11 μM), and can be released from these slices by an increased potassium ion concentration in a calcium‐dependent manner. Nipecotic acid and GABA appear to be taken up by the same osmotically‐sensitive structures. GABA and substances which inhibit GABA uptake also inhibit the uptake of nipecotic acid. GABA can release preloaded nipecotic acid from brain slices, and nipecotic acid can release preloaded GABA. This indicates that GABA and nipecotic acid can be counter‐transported using the same mobile carrier. Nipecotic acid appears to have a higher affinity than GABA for this carrier.Keywords
This publication has 14 references indexed in Scilit:
- Selective uptake of [3H]β-alanine by glia: Association with the glial uptake system for GABABrain Research, 1975
- Potassium-induced release of amino acids from cerebral cortex and spinal cord slices of the ratBrain Research, 1974
- POSTNATAL CHANGES IN THE HIGH AFFINITY UPTAKE OF GLYCINE and GABA IN THE RAT CENTRAL NERVOUS SYSTEMJournal of Neurochemistry, 1974
- The effects of l-2,4-diaminobutyric acid on the uptake of gamma-aminobutyric acid by a synaptosomal fraction from rat brainArchives of Biochemistry and Biophysics, 1973
- Bicuculline Methochloride as a GABA AntagonistNature New Biology, 1972
- COMPETITIVE INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY SOME GABA ANALOGUES OF RESTRICTED CONFORMATIONJournal of Neurochemistry, 1972
- GABA UPTAKE IN RAT CENTRAL NERVOUS SYSTEM: COMPARISON OF UPTAKE IN SLICES AND HOMOGENATES AND THE EFFECTS OF SOME INHIBITORSJournal of Neurochemistry, 1971
- Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the catBrain Research, 1971
- THE UPTAKE OF [3H]GABA BY SLICES OF RAT CEREBRAL CORTEXJournal of Neurochemistry, 1968
- A Simple Preparation of Nipecotic AcidThe Journal of Organic Chemistry, 1963