Reactivity of 3‐amino‐3H‐quinazolin‐4‐one derivatives towards some electrophilic and nucleophilic reagents and using of the products in the building of some interesting heterocycles as anticancer agent
- 1 May 2006
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 43 (3) , 527-534
Abstract
Magnified image The chemical reactivity of N‐[1‐(3‐amino‐6,8‐dibromo‐4‐oxo‐3,4‐dihydro‐quinazolin‐2‐yl)‐2‐(2‐chlorophenyl)‐vinyl]benzamide (3) towards electrophilic and nucleophilic reagents have been reported. Structures of the products 3‐24 have been confirmed by elemental analysis and spectral data (IR, 1H‐NMR, 13C and MS). The bioassay indicates that some of the prepared compounds have a good selective anticancer activity.Keywords
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