Genetic associations of eosinophilic granulomatosis with polyangiitis in the Japanese population: exploring similarities and differences with European populations

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Abstract
Objectives: Eosinophilic granulomatosis with polyangiitis (EGPA) is classified as a subtype of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). A recent genome-wide association study (GWAS) of EGPA in populations of European ancestry reported several susceptibility loci. In view of population differences in genetic factors of AAV, we made an attempt to examine the contribution of these loci to EGPA in a Japanese population. Methods: The EGPA-associated variants in LPP , TSLP , IRF1 / IL5 , HLA , CDK6 , 10p14 and 12q21 in European populations (EUR) were analysed in a total of 103 Japanese patients with EGPA, including 48 myeloperoxidase (MPO)-ANCA-positive and 45 ANCA-negative patients. Allele frequency data on approximately 60 000 Japanese individuals from the Japanese Multi Omics Reference Panel served as the controls. Results: An increasing tendency in TSLP rs1837253 C allele was observed in total EGPA, MPO-ANCA-positive EGPA and ANCA-negative EGPA. In addition, association of HLA-DRB1*07:01 was observed in total EGPA and MPO-ANCA-positive EGPA. These findings supported the previous findings in the EUR. On the other hand, unlike in the EUR, association of DRB1*09:01 was observed in Japanese EGPA. With respect to amino acid residues in HLA-DRβ1, Val 78 encoded by DRB1*07:01 and * 09:01 was associated with total EGPA and MPO-ANCA-positive EGPA with genome-wide significance (pTSLP was suggested to be associated with EGPA both in the European and Japanese populations regardless of the ANCA status. In HLA-DRB1 , both shared and population-specific susceptibility alleles were observed.
Funding Information
  • Uehara Memorial Foundation
  • Japan Rheumatism Foundation
  • Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
  • Japan Agency for Medical Research and Development “The Study Group for Strategic Exploration of Drug Seeds for ANCA (17ek0109104h0003)
  • Japan Agency for Medical Research and Development “The Study Group for Strategic Exploration of Drug Seeds for ANCA (17ek0109121h0003)
  • Japan Agency for Medical Research and Development “The Study Group for Strategic Exploration of Drug Seeds for ANCA (20ek0109360h003)
  • Ministry of Health, Labour and Welfare (23FC1019)
  • Ministry of Health, Labour and Welfare (JPMH20FC1044)
  • Japan Society for the Promotion of Science (25K11700)
  • Japan Society for the Promotion of Science (JP17K09967)
  • Japan Society for the Promotion of Science (JP21K08435)
  • Japan College of Rheumatology
  • Bristol-Myers Squibb K.K
  • H.U. Group Research Institute G.K.
  • Takeda Science Foundation

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